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Molecular Beacons
Design or evaluate standard molecular beacons or molecular beacons for NASBA® assays. NASBA® is a primer-dependent technology that can be used for the continuous amplification of nucleic acids in a single mixture at one temperature. You can now design molecular beacons for NASBA® assays for single template or multiplex reactions.
SYBR® Green is perhaps the most commonly used real time PCR chemistry. Beacon Designer™ designs SYBR® Green PCR primers and helps you evaluate pre-designed SYBR® Green PCR primer sets. You have complete control over the design parameters or you can use the default values, chosen after considerable research and communication with experts. You can even choose your own default design parameters for your specific research needs.
The DNA sample is first treated with sodium bisulphite which converts the unmethylated cytosine bases to . The methylated cytosines on the other hand, remain unaffected. Methyl Specific primers are designed to anneal with bisulphite converted DNA. This sample is amplified by PCR replacing the with thymine. A TaqMan® probe is then used to detect the methylated strand.
双标记探针的设计
Beacon Designer目前支持四种基于探针的化学物质：
TaqMan探针
使用Beacon Designer优化TaqMan探针，帮助您研究差异基因表达或使用TaqMan SNP基因型检验研究SNP（单核苷酸多态性）。您也可以选择设计越来越流行的锁定核酸（LNA）取代TaqMan探针，这些探针比标准TaqMan探针更稳定。为了研究DNA甲基化，Beacon Designer帮助设计引物和TaqMan探针进行甲基化分析。甲基光是一种高通量分析，用于区分甲基化和非甲基化DNA。使用Beacon Designer，通过设计甲基化和未甲基化链的寡核苷酸，以及未经处理的DNA序列，可以设计合适的控制引物和探针。有了这些化学物质，您可以评估预先设计的引物或TaqMan探针。设计结果按顺序排列，给您一个可供选择的替代品列表。根据oligo的属性分配等级。
SYBR® Green Primer Design
TaqMan® Probe Design
Multiplex Real Time PCR Assay Design
HRMA Primer Design
MethyLight TaqMan® Design
Molecular Beacon Design
NASBA® Assay Design
FRET Probe Design
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